By the early 1400s, diplomatic representatives and pilgrims from the Christian Kingdom of Ethiopia had traveled to the Italian peninsula for political and religious reasons. In doing so, they inaugurated an era of Ethiopian–European relations that unfolded for more than 200 years: Ethiopians reached multiple locales across Latin Europe to forge political alliances, acquire technology, and pursue religious knowledge. They drew the attention of European observers, especially those with an interest in the overseas. Secular and religious personalities, but also average merchants, began their quests for the Ethiopian highlands, lured by the tales of their visitors who were believed with growing certainty to be subjects of the mythical Prester John, the imaginary Christian sovereign believed to rule the Indies. Their journeys enabled cultural exchanges, technological transfer, and the forging of one of the first Euro-African political alliances, that between the kingdoms of Ethiopia and Portugal.
In the 15th century, Ethiopian pilgrims flocked to Rome, and diplomatic representatives found hospitality in the Venetian Republic and at the Aragonese and papal courts. Concurrently with Ethiopian arrivals in Europe, European adventurers and representatives began reaching Ethiopia, eventually leading to the establishing of Portuguese–Ethiopian relations. The exchanges climaxed with a Portuguese military intervention to support the Ethiopian monarchy against the sultanate of Adal in 1541. In the decades following the conflict, Jesuit missionaries began operating in the country: after a difficult inception in the 1620s, the fathers experienced ephemeral successes, followed by a dramatic expulsion that ended early modern Ethiopian–European relations.