Since their inception, precolonial mining and metallurgy gradually became essential social, technological, and even politico-economic pillars of African communities of varying time periods. However, the onset of metallurgy and mining and the associated technology and sociocultural beliefs varied from region to region in a way that defies generalization. Owing to their cultural and geographical location, Egypt, the Sudan, North Africa, and the Horn of Africa share some very broad similarities in their metallurgical histories. This in some cases sharply differs from that of many regions such as West, central, East and southern Africa. Interestingly, these regions too are characterized by technological similarity and diversity. When considered together, the multiple trajectories taken by metallurgy and mining in Africa’s different regions are essential for achieving a comparative understanding of the continent’s rich technological history. Achieving this, however, requires an interdisciplinary approach from documentation through data analysis to eventual interpretation. This contribution combines insights from various disciplines to present an overview of precolonial metallurgy and mining in Africa’s many regions.